Distrofia Muscular
Dissertações: Distrofia Muscular. Pesquise 862.000+ trabalhos acadêmicosPor: ju_deutsche • 8/8/2014 • 3.784 Palavras (16 Páginas) • 434 Visualizações
Copyright @ 2007 by the American College of Sports Medicine. Unauthorized reproduction of this article is prohibited.
Recommendations to Define Exercise Prescription
for Duchenne Muscular Dystrophy
Robert W. Grange and Jarrod A. Call
Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University,
Blacksburg, VA, United States
GRANGE, R.W., and J.A. CALL. Recommendations to define exercise prescription for duchenne muscular dystrophy. Exerc.
Sport Sci. Rev., Vol. 35, No. 1, pp. 12Y17, 2007. Duchenne muscular dystrophy yields pervasive and progressive muscle weakness.
This weakness may be attenuated by regular, low-intensity exercise. However, there is a critical lack of data to support appropriate
exercise prescription. Because inappropriate activity may exacerbate the dystrophic process, a systematic analysis of muscle function
to determine potential exercise load thresholds to avoid injury in dystrophic mice and dogs, and then in humans, is recommended.
Key Words: muscle injury, mdx mice, mdx:utrophin-/- mice, exercise prescription
INTRODUCTION
Muscular dystrophy describes a group of approximately 40
inherited heterogeneous disorders characterized by progressive
muscle weakness and muscle wasting (6). Duchenne
muscular dystrophy (DMD) is the most severe and fatal,
affecting 1/3500 boys (7). DMD is characterized by progressive
loss of contractile function caused by the absence of
the membrane-associated protein, dystrophin, and the associated
proteins of the dystrophin glycoprotein complex (6).
However, at present, the specific pathophysiological mechanisms
that lead to onset of the disease have not yet been
clearly defined.
DMD is an X chromosomeYlinked recessive disorder only
affecting the male population, although some female carriers
are mildly affected. DMD has a childhood onset and often
occurs in children within the same family. Coincident with
progressive muscle weakness is a gradual increase in the size
of many affected muscles known as pseudohypertrophy. The
later stages of the disease are characterized by abundant
fibrosis and adipose tissue within the muscle (7). Therapeutics
that are currently being used and developed for DMD
include drug and gene interventions. Although some drugs
are already being used to treat DMD patients (e.g., prednisone),
gene therapy has been limited to animal models.
Because DMD is characterized by weak muscles, and overload
resistance training is known to improve muscle strength, this
should be a suitable therapy. For example, exercise has been
used effectively to attenuate the loss of muscle strength and
endurance with aging, but is there sufficient data in the
literature to justify a sound exercise prescription to blunt or
reverse the effects of DMD? Unfortunately, none. Limited use
of exercise has been reported for patients with muscular
dystrophy for approximately 50 yr, and is considered to be
beneficial by some if performed at low intensity (2), but
definitive human studies on the use of exercise as a treatment
have not been conducted (Fig. 1). Determining the parameters
of exercise prescription is not a simple case of assessing
various training paradigms to improve muscle strength in
those with DMD because exercise itself could exacerbate
muscle damage. Thus, the limits to improve muscle function
and minimize muscle damage must be carefully established.
The purpose of this article is to propose that the exercise
prescription necessary to improve strength and muscle
endurance needs to be determined for individuals with
DMD. It is suggested that a systematic analysis in dystrophic
mice to establish musclefunctional capabilities and
adaptations may be the safest approach to define the fundamentals
of this exercise prescription.
DMD AND PHYSICAL ACTIVITY
Exercise, if properly prescribed and performed, is known to
improve physiological capacities of muscle such as strength
12
ARTICLE
Address for correspondence: Robert W. Grange, Ph.D., Department of Human
Nutrition, Foods and Exercise, Wallace Hall 321, Virginia Polytechnic Institute and
State University, Blacksburg VA 24061-0430 (E-mail: rgrange@vt.edu).
Accepted for publication: June 26, 2006.
Associate Editor: Gordon L. Warren, Ph.D.
0091-6331/3501/12Y17
Exercise and Sciences Reviews
Copyright
...